Cost Effectiveness of Age-Specific Screening Intervals for People With Family Histories of Colorectal Cancer.

ABSTRACT:

Background & aims

Relative risk of colorectal cancer (CRC) decreases with age among individuals with a family history of CRC. However, no screening recommendations specify less frequent screening with increasing age. We aimed to determine whether such a refinement would be cost effective.

Methods

We determined the relative risk for CRC for individuals based on age and number of affected first-degree relatives (FDRs) using data from publications. For each number of affected FDRs, we used the Microsimulation Screening Analysis model to estimate costs and effects of colonoscopy screening strategies with different age ranges and intervals. Screening was then optimized sequentially, starting with the youngest age group, and allowing the interval of screening to change at certain

SUBMITTER: Naber SK 

PROVIDER: S-EPMC6104831 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature