A novel method of inducing endogenous pupil oscillations to detect patients with unilateral optic neuritis.

ABSTRACT:

Purpose

To use and test a new method of inducing endogenously generated pupillary oscillations (POs) in patients with unilateral optic neuritis (ON), to describe a signal analysis approach quantifying pupil activity and to evaluate the extent to which POs permit to discriminate patients from control participants.

Method

Pupil size was recorded with an eye-tracker and converted in real time to modulate the luminance of a stimulus (a 20° disk) presented in front of participants. With this biofeedback setting, an increasing pupil size transforms into a high luminance, entraining a pupil constriction that in turn decreases the stimulus luminance, and so on, resulting in endogenously generated POs. POs were recorded for 30 seconds in the affected eye, in the fellow eye and in bin

SUBMITTER: Lamirel C 

PROVIDER: S-EPMC6104938 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature