Trans fatty acids in adipose tissue and risk of myocardial infarction: A case-cohort study.

ABSTRACT:

Background

The risk of coronary heart disease associated with intake of individual trans fatty acids (TFAs) is not clear. Adipose tissue content of TFAs is a biomarker of TFA intake and metabolism.

Objective

We investigated the rate of myocardial infarction (MI) associated with the adipose tissue content of total 18:1t, isomers of 18:1t (18:1 Δ6-10t and 18:1 Δ11t) and 18:2 Δ9c, 11t.

Methods

A case-cohort study, nested within the Danish Diet, Cancer and Health cohort (n = 57,053), was conducted, which included a random sample (n = 3156) of the total cohort and all incident MI cases (n = 2148) during follow-up (14 years). Information on MI cases was obtained by linkage with nationwide registers and validated. Adipose tissue was taken from the participants buttocks and t

SUBMITTER: Jakobsen MU 

PROVIDER: S-EPMC6104995 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature