Incretin-Based Therapies and Diabetic Retinopathy: Real-World Evidence in Older U.S. Adults.

ABSTRACT:

Objective

Recent large trials yield conflicting results on the association between incretin-based therapies (IBTs) and diabetic retinopathy (DR). We examined whether IBTs increase DR risk compared with other antihyperglycemics.

Research design and methods

We implemented an active comparator, new-user cohort design using a nationwide 20% random sample of fee-for-service U.S. Medicare beneficiaries aged 65 years or older with Parts A, B, and D coverage between 2007 and 2015. We identified the following cohorts without prior treatment for retinopathy: dipeptidyl peptidase 4 inhibitors (DPP4i) versus sulfonylureas (SU), DPP4i versus thiazolidinediones (TZD), glucagon-like peptide-1 receptor agonists (GLP1RA) versus long-acting insulin (LAI), and GLP1RA versus TZD. Primary outcom

SUBMITTER: Wang T 

PROVIDER: S-EPMC6105327 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature