Electrical impedance myography in facioscapulohumeral muscular dystrophy: A 1-year follow-up study.

ABSTRACT:

Introduction

Electrical impedance myography (EIM) is a noninvasive technique for measuring muscle composition and a potential physiological biomarker for facioscapulohumeral muscular dystrophy (FSHD).

Methods

Thirty-two participants with genetically confirmed and clinically affected FSHD underwent EIM in 7 muscles bilaterally. Correlations between EIM and baseline clinical measures were used to select EIM variables of interest in FSHD, and EIM and clinical measures were followed for 1 year.

Results

There were no significant changes in the EIM variables. Although 50-kHZ reactance correlated the strongest with clinical measures at baseline, the 50-211-kHZ phase ratio demonstrated lower within-subject 12-month variability, potentially offering sample size savings for FSH

SUBMITTER: Mul K 

PROVIDER: S-EPMC6105423 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature