Aligning physics and physiology: Engineering antibodies for radionuclide delivery.

ABSTRACT: The exquisite specificity of antibodies and antibody fragments renders them excellent agents for targeted delivery of radionuclides. Radiolabeled antibodies and fragments have been successfully used for molecular imaging and radioimmunotherapy (RIT) of cell surface targets in oncology and immunology. Protein engineering has been used for antibody humanization essential for clinical applications, as well as optimization of important characteristics including pharmacokinetics, biodistribution, and clearance. Although intact antibodies have high potential as imaging and therapeutic agents, challenges include long circulation time in blood, which leads to later imaging time points post-injection and higher blood absorbed dose that may be disadvantageous for RIT. Using engineered fragments may

SUBMITTER: Tsai WK 

PROVIDER: S-EPMC6105424 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature