Newborn adipokines and early childhood growth.

ABSTRACT:

Background

While adipokines can regulate satiety and energy metabolism, whether they are associated with childhood growth is unclear.

Objective

To evaluate whether adipokine levels at birth are associated with growth.

Methods

A total of 2264 singletons and 1144 twins from Upstate KIDS (born 2008-2010) had adiponectin, leptin, resistin and complement factor D measured in newborn blood spots. Parents reported anthropometry from paediatric visits via questionnaires every 4-6 months. Generalized linear mixed effects models were used to estimate growth trajectories through 3 years of age.

Results

Among singletons, resistin and leptin were associated with greater weight-for-age (0.12 z-score units (95%CI: 0.04, 0.20) [p = 0.003] and 0.15 (0.06, 0.24) [p = 0.001], res

SUBMITTER: Yeung EH 

PROVIDER: S-EPMC6105426 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature