Reduced embryonic blood flow impacts extracellular matrix deposition in the maturing aorta.

ABSTRACT:

Background

Perturbations to embryonic hemodynamics are known to adversely affect cardiovascular development. Vitelline vein ligation (VVL) is a model of reduced placental blood flow used to induce cardiac defects in early chick embryo development. The effect of these hemodynamic interventions on maturing elastic arteries is largely unknown. We hypothesize that hemodynamic changes impact maturation of the dorsal aorta (DA).

Results

We examined the effects of VVL on hemodynamic properties well into the maturation process and the corresponding changes in aortic dimensions, wall composition, and gene expression. In chick embryos, we found that DA blood velocity was reduced immediately postsurgery at Hamburger-Hamilton (HH) stage 18 and later at HH36, but not in the interim. Thro

SUBMITTER: Espinosa MG 

PROVIDER: S-EPMC6105494 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature