Dopamine-Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study.

ABSTRACT:

Objectives

To determine whether intervention-induced physical activity (PA) changes in sedentary older adults differed according to dopamine-related genotype.

Design

Randomized clinical trial (Lifestyle Interventions and Independence for Elders Trial (2010-13)).

Setting

Multicenter study, 8 U.S.

Locations

Participants

Volunteer sample of sedentary adults aged 70 to 89 at risk of disability (N=1635).

Interventions

Structured PA versus health education (HE) for an average of 2.6 years.

Measurements

Single-nucleotide polymorphisms of dopamine-related genes (dopamine receptor (DR) D1, DRD2, DRD3, and catechol-O-methyltransferase (COMT)) were assessed. Average moderate to vigorous PA (MVPA) was calculated using accelerometry (min/d) at baseline

SUBMITTER: Rosso AL 

PROVIDER: S-EPMC6105503 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature