Female reproductive history and risk of type 2 diabetes: A prospective analysis of 126 721 women.

ABSTRACT:

Aim

To examine the prospective associations between aspects of a woman's reproductive history and incident diabetes.

Methods

We pooled individual data from 126 721 middle-aged women from eight cohort studies contributing to the International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE). Associations between age at menarche, age at first birth, parity and menopausal status with incident diabetes were examined using generalized linear mixed models, with binomial distribution and robust variance. We stratified by body mass index (BMI) when there was evidence of a statistical interaction with BMI.

Results

Over a median follow-up of 9 years, 4073 cases of diabetes were reported. Non-linear associations with diabetes

SUBMITTER: Pandeya N 

PROVIDER: S-EPMC6105508 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature