Sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide levels in the general population.

ABSTRACT:

Background

Obese subjects have lower natriuretic peptide levels, but males and females have different anthropometric characteristics and fat distribution. Whether obesity-associated lowering of natriuretic peptides differs among males and females is unknown. Therefore, we investigated sex-specific associations of obesity and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels among adults in the general population.

Methods and results

Using 8260 participants (50.1% females) from the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) cohort, we evaluated the relationship of NT-proBNP levels with obesity-associated parameters, i.e. waist circumference (WC), body mass index (BMI) and body weight in the overall population, and in males and females separately.

SUBMITTER: Suthahar N 

PROVIDER: S-EPMC6105520 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature