Integrated magnetic resonance imaging and [¹¹ C]-PBR28 positron emission tomographic imaging in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To characterize [¹¹ C]-PBR28 brain uptake using positron emission tomography (PET) in people with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). We have previously shown increased [¹¹ C]-PBR28 uptake in the precentral gyrus in a small group of ALS patients. Herein, we confirm our initial finding, study the longitudinal changes, and characterize the gray versus white matter distribution of [¹¹ C]-PBR28 uptake in a larger cohort of patients with ALS and PLS.

Methods

Eighty-five participants including 53 with ALS, 11 with PLS, and 21 healthy controls underwent integrated [¹¹ C]-PBR28 PET-magnetic resonance brain imaging. Patients were clinically assessed using the Upper Motor Neuron Burden (UMNB) an

SUBMITTER: Alshikho MJ 

PROVIDER: S-EPMC6105567 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature