Ontology highlight
ABSTRACT:
SUBMITTER: Principe DR
PROVIDER: S-EPMC6105629 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20180822 1
Although survival has improved in recent years, the prognosis of patients with advanced pancreatic ductal adenocarcinoma (PDAC) remains poor. Despite substantial differences in anatomy, physiology, genetics, and metabolism, the overwhelming majority of preclinical testing relies on transgenic mice. Hence, while mice have allowed for tremendous advances in cancer biology, they have been a poor predictor of drug performance/toxicity in the clinic. Given the greater similarity of sus scrofa pigs to ...[more]