Bare surface of gold nanoparticle induces inflammation through unfolding of plasma fibrinogen.

ABSTRACT: The surface of nanoparticles (NPs) get coated by a wide range of biomolecules, upon exposure to biological fluids. It is now being increasingly accepted that NPs with particular physiochemical properties have a capacity to induce conformational changes to proteins and therefore influence their biological fates, we hypothesized that the gold NP's metal surface may also be involved in the observed Fg unfolding and inflammatory response. To mechanistically test this hypothesis, we probed the interaction of Fg with gold surfaces using molecular dynamic simulation (MD) and revealed that the gold surface has a capacity to induce Fg conformational changes in favor of inflammation response. As the integrity of coatings at the surface of ultra-small gold NPs are not thorough, we also hypothesized t

SUBMITTER: Kharazian B 

PROVIDER: S-EPMC6105630 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature