Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies.

ABSTRACT: Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgently needed. The highly conserved influenza virus hemagglutinin (HA) stalk represents one of the potential targets of broadly protective/universal influenza virus vaccines. Here, we evaluate a potent broadly protective influenza virus vaccine candidate that uses nucleoside-modified and purified mRNA encoding full-length influenza virus HA formulated in lipid nanoparticles (LNPs). We demonstrate that immunization with HA mRNA-LNPs induces antibody responses against the HA stalk domain of influenza virus in mice, rabbits, and

SUBMITTER: Pardi N 

PROVIDER: S-EPMC6105651 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature