Corticosterone induces growth hormone expression in pituitary somatotrophs during goose embryonic development.

ABSTRACT: Treatment of fetal rat and embryonic chicken with exogenous glucocorticoids induces premature differentiation of growth hormone (GH) secreting cells. The effect of corticosterone (CORT) on somatotroph differentiation was mostly studied in pituitary cells in vitro. Currently, there is no evidence for glucocorticoid-mediated induction of somatotroph differentiation during pituitary development in bird species other than chicken. In this study, we sought to find out if in ovo injection of corticosterone into developing goose embryos could induce premature increase of GH in somatotrophs. On embryonic day (e) 15, the albumen of fertile goose eggs was injected with 300 μl of 0.9% saline, 300 μl 5 × 10^-8M CORT, or 300 μl 5 × 10^-6 M CORT. Embryos were allowed to develop until

SUBMITTER: Yu J 

PROVIDER: S-EPMC6105744 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature