Clonal Background, Resistance Gene Profile, and Porin Gene Mutations Modulate In Vitro Susceptibility to Imipenem-Relebactam in Diverse Enterobacteriaceae.

ABSTRACT: Treatment options for carbapenem-resistant Enterobacteriaceae (CRE) are limited. While Klebsiella pneumoniae strains harboring bla_KPC account for most CRE, recent evidence points to increasing diversification of CRE. We determined whether the CRE species and antibiotic resistance genotype influence the response to relebactam (REL), a novel beta-lactamase inhibitor with class A/C activity, combined with imipenem-cilastatin (IMI). We carried out broth microdilution testing with IMI alone or in the presence of 4 μg/ml REL against 154 clinical isolates collected at a New York City hospital with a high prevalence of organisms carrying bla_KPC, including Enterobacter spp. (n = 96), K. pneumoniae (n = 44), Escherichia

SUBMITTER: Gomez-Simmonds A 

PROVIDER: S-EPMC6105792 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature