Unknown

Dataset Information

0

Genetic and Biochemical Characterization of OXA-519, a Novel OXA-48-Like ?-Lactamase.

ABSTRACT: A multidrug-resistant Klebsiella pneumoniae 1210 isolate with reduced carbapenem susceptibility revealed the presence of a novel plasmid-encoded blaOXA-48-like gene, named blaOXA-519 The 60.7-kb plasmid (pOXA-519) was similar to the IncL-OXA-48 prototypical plasmid except for a ca. 2-kb deletion due to an IS1R insertion. OXA-519 differed from OXA-48 by a Val120Leu substitution, which resulted in an overall reduced ?-lactam-hydrolysis profile, except those for ertapenem and meropenem, which were increased. Thus, detection of OXA-519 producers using biochemical tests that monitor imipenem hydrolysis will be difficult.

SUBMITTER: Dabos L 

PROVIDER: S-EPMC6105830 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genetic and Biochemical Characterization of OXA-519, a Novel OXA-48-Like β-Lactamase.

Dabos Laura L   Bogaerts Pierre P   Bonnin Remy A RA   Zavala Agustin A   Sacré Pierre P   Iorga Bogdan I BI   Huang Daniel T DT   Glupczynski Youri Y   Naas Thierry T  

Antimicrobial agents and chemotherapy 20180727 8

A multidrug-resistant <i>Klebsiella pneumoniae</i> 1210 isolate with reduced carbapenem susceptibility revealed the presence of a novel plasmid-encoded <i>bla</i><sub>OXA-48-like</sub> gene, named <i>bla</i><sub>OXA-519</sub> The 60.7-kb plasmid (pOXA-519) was similar to the IncL-OXA-48 prototypical plasmid except for a ca. 2-kb deletion due to an IS<i>1R</i> insertion. OXA-519 differed from OXA-48 by a Val120Leu substitution, which resulted in an overall reduced β-lactam-hydrolysis profile, exc  ...[more]

Similar Datasets

Unknown Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like ?-Lactamase.
| S-EPMC6153822 | biostudies-literature
Unknown Genetic and biochemical characterization of OXA-405, an OXA-48-type extended-spectrum β-lactamase without significant carbapenemase activity.
| S-EPMC4468662 | biostudies-literature
Unknown Biochemical and Structural Characterization of OXA-405, an OXA-48 Variant with Extended-Spectrum β-Lactamase Activity.
| S-EPMC7022249 | biostudies-literature
Unknown Biochemical and biophysical characterization of the OXA-48-like carbapenemase OXA-436.
| S-EPMC8411929 | biostudies-literature
Unknown Biochemical and genetic characterization of carbapenem-hydrolyzing ?-lactamase OXA-229 from Acinetobacter bereziniae.
| S-EPMC3393453 | biostudies-literature
Unknown Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
| S-EPMC2292554 | biostudies-literature
Unknown Discovery of Novel Chemical Series of OXA-48 β-Lactamase Inhibitors by High-Throughput Screening.
| S-EPMC8308845 | biostudies-literature
Unknown OXA-163, an OXA-48-related class D ?-lactamase with extended activity toward expanded-spectrum cephalosporins.
| S-EPMC3101449 | biostudies-literature
Unknown Biochemical-genetic characterization and distribution of OXA-22, a chromosomal and inducible class D beta-lactamase from Ralstonia (Pseudomonas) pickettii.
| S-EPMC90041 | biostudies-literature
Unknown OXA-484, an OXA-48-Type Carbapenem-Hydrolyzing Class D β-Lactamase From <i>Escherichia coli</i>.
| S-EPMC8153228 | biostudies-literature