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Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria.

ABSTRACT: The activities of four oxadiazoles were investigated with 210 methicillin-resistant Staphylococcus aureus (MRSA) strains. MIC50 and MIC90 values of 1 to 2 and 4 ?g/ml, respectively, were observed. We also evaluated the activity of oxadiazole ND-421 against other staphylococci and enterococci and in the presence of oxacillin for selected MRSA strains. The MIC for ND-421 is lowered severalfold in combination with oxacillin, as they synergize. The MIC90 of ND-421 against vancomycin-resistant enterococci is ?1 ?g/ml.

SUBMITTER: Ceballos S 

PROVIDER: S-EPMC6105842 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria.

Ceballos Sara S   Kim Choon C   Ding Derong D   Mobashery Shahriar S   Chang Mayland M   Torres Carmen C  

Antimicrobial agents and chemotherapy 20180727 8

The activities of four oxadiazoles were investigated with 210 methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) strains. MIC<sub>50</sub> and MIC<sub>90</sub> values of 1 to 2 and 4 μg/ml, respectively, were observed. We also evaluated the activity of oxadiazole ND-421 against other staphylococci and enterococci and in the presence of oxacillin for selected MRSA strains. The MIC for ND-421 is lowered severalfold in combination with oxacillin, as they synergize. The MIC<sub>90</sub> of ND  ...[more]

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