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Emergence of Azole-Resistant Aspergillus fumigatus from Immunocompromised Hosts in India.

ABSTRACT: This prospective study shows that the rate of azole-resistant Aspergillus fumigatus (ARAF) in an immunocompromised Indian patient population with invasive aspergillosis (IA) is low, 6/706 (0.8%). This low rate supports the continued use of voriconazole as the first line of treatment. However, the ARAF isolates from India in this study exhibited three kinds of unreported cyp51A mutations, of which two were at hot spots, G54R and P216L, while one was at codon Y431C.

SUBMITTER: Dabas Y 

PROVIDER: S-EPMC6105863 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Emergence of Azole-Resistant Aspergillus fumigatus from Immunocompromised Hosts in India.

Dabas Yubhisha Y   Xess Immaculata I   Bakshi Sameer S   Mahapatra Manoranjan M   Seth Rachna R  

Antimicrobial agents and chemotherapy 20180727 8

This prospective study shows that the rate of azole-resistant <i>Aspergillus fumigatus</i> (ARAF) in an immunocompromised Indian patient population with invasive aspergillosis (IA) is low, 6/706 (0.8%). This low rate supports the continued use of voriconazole as the first line of treatment. However, the ARAF isolates from India in this study exhibited three kinds of unreported <i>cyp51A</i> mutations, of which two were at hot spots, G54R and P216L, while one was at codon Y431C. ...[more]

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