The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome.

ABSTRACT: The intracellular parasite Toxoplasma gondii promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine macrophages with type I or II T. gondii strains causes a profound perturbation of the host cell translatome. Notably, translation of transcripts encoding proteins involved in metabolic activity and components of the translation machinery was activated upon infection. In contrast, the translational efficiency of mRNAs related to immune cell activation and cytoskeleton/cytoplasm organization was largely suppressed. Mechanistically, T. gondii bolstered mechanistic target of rapamycin (mTOR) signaling to selectively activate the translation of mTOR-sensi

SUBMITTER: Leroux LP 

PROVIDER: S-EPMC6105892 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature