CtDNA assessment of EGFR mutation status in Chinese patients with advanced non-small cell lung cancer in real-world setting.

ABSTRACT:

Background

The prevalence of EGFR mutations in circulating free tumor-derived DNA (ctDNA) was still unknown in China. This large-scale study (NCT02623257) aimed to explore the prevalence of epidermal growth factor receptor (EGFR) mutations and determine the correlation of EGFR mutation status with clinical characteristics.

Methods

Plasma DNA samples from 1,001 patients with stage III/IV NSCLC who received ≤1st line chemotherapy were collected from 65 hospitals. EGFR mutations were tested by amplification refractory mutation system (ARMS) method. The EGFR mutation rate was calculated and the associations between EGFR status and patients' demographic data, disease status as well as treatment pattern were explored.

Results

EGFR mutations were detected in 251 of 1,001 (25

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6105939 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature