High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis.

ABSTRACT: The innate immune system is the first line of defense against invasive fungal infections. As a consequence, many successful fungal pathogens have evolved elegant strategies to interact with host immune cells. For example, Candida albicans undergoes a morphogenetic switch coupled to cell wall remodeling upon phagocytosis by macrophages and then induces macrophage pyroptosis, an inflammatory cell death program. To elucidate the genetic circuitry through which C. albicans orchestrates this host response, we performed the first large-scale analysis of C. albicans interactions with mammalian immune cells. We identified 98 C. albicans genes that enable macrophage pyroptosis without influencing fungal cell morphology in the macrophage, including specific determinants o

SUBMITTER: O'Meara TR 

PROVIDER: S-EPMC6106084 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature