Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack.

ABSTRACT: Candida auris has recently emerged as the first fungal pathogen to cause a global public health threat. The reason this species is causing hospital-associated outbreaks of invasive candidiasis with high mortality is unknown. In this study, we examine the interaction of C. auris with neutrophils, leukocytes critical for control of invasive fungal infections. We show that human neutrophils do not effectively kill C. auris Compared to Candida albicans, neutrophils poorly recruited to C. auris and failed to form neutrophil extracellular traps (NETs), which are structures of DNA, histones, and proteins with antimicrobial activity. In mixed cultures, neutrophils preferentially engaged and killed C. albicans over C. auris Imaging of neutrophils in

SUBMITTER: Johnson CJ 

PROVIDER: S-EPMC6106086 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature