Periodic Variation of Mutation Rates in Bacterial Genomes Associated with Replication Timing.

ABSTRACT: The causes and consequences of spatiotemporal variation in mutation rates remain to be explored in nearly all organisms. Here we examine relationships between local mutation rates and replication timing in three bacterial species whose genomes have multiple chromosomes: Vibrio fischeri, Vibrio cholerae, and Burkholderia cenocepacia Following five mutation accumulation experiments with these bacteria conducted in the near absence of natural selection, the genomes of clones from each lineage were sequenced and analyzed to identify variation in mutation rates and spectra. In lineages lacking mismatch repair, base substitution mutation rates vary in a mirrored wave-like pattern on opposing replichores of the large chromosomes of V. fischeri and V. cholerae, w

SUBMITTER: Dillon MM 

PROVIDER: S-EPMC6106087 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature