Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis.

ABSTRACT:

Context

Progesterone (P) resistance is a hallmark of endometriosis, but the underlying mechanism(s) for loss of P sensitivity leading to lesion establishment remains poorly understood.

Objective

To evaluate the association between Notch-1 signaling activation and P resistance in the progression of endometriosis.

Design

Case control study; archived formalin-fixed, paraffin-embedded tissues.

Setting

University hospitals (United States, Taiwan).

Patients

Women with endometriosis; human endometrial stromal cell line (HESC).

Intervention

Eutopic endometria (EU) and ectopic lesions (ECs) were collected from surgically diagnosed patients. Archived tissue sections of EU and ECs were identified. HESCs were treated with N-[N-(3,5-difluorophena

SUBMITTER: Brown DM 

PROVIDER: S-EPMC6106104 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature