Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease.

ABSTRACT:

Objective

Impaired repetitive movement in persons with Parkinson's disease (PD) is associated with reduced amplitude, paradoxical hastening and hesitations or arrest at higher movement rates. This study examined the effects of movement rate and medication on movement-related cortical oscillations in persons with PD.

Methods

Nine participants with PD were studied off and on medication and compared to nine control participants. Participants performed index finger movements cued by tones from 1 to 3 Hz. Movement-related oscillations were derived from electroencephalographic recordings over the region of the contralateral sensorimotor cortex (S1/M1) during rest, listening, or synchronized movement.

Results

At rest, spectral power recorded over the region of the contralate

SUBMITTER: Stegemoller EL 

PROVIDER: S-EPMC6106791 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature