Welding fume exposure is associated with inflammation: a global metabolomics profiling study.

ABSTRACT:

Background

Increasing evidence suggests that welding fume exposure is associated with systemic inflammation. Although celluar metabolites may be associated with inflammation, there is limited information on metabolomic changes during welding fume exposure. Such changes may play an important role in the occurrence, development, and prevention of metal-associated diseases. We aim to investigate human metabolomics changes pre- and post-welding fume exposure.

Methods

This study included 52 boilermakers totally. We collected plasma samples pre- and post-shift welding fume exposure and prepared samples using the automated MicroLab STAR® system. Metabolite concentrations were measured using ultra performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) methods. Two

SUBMITTER: Shen S 

PROVIDER: S-EPMC6106842 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature