Decarboxylative sp³ C-N coupling via dual copper and photoredox catalysis.

ABSTRACT: Over the past three decades, considerable progress has been made in the development of methods to construct sp² carbon-nitrogen (C-N) bonds using palladium, copper or nickel catalysis^1,2. However, the incorporation of alkyl substrates to form sp³ C-N bonds remains one of the major challenges in the field of cross-coupling chemistry. Here we demonstrate that the synergistic combination of copper catalysis and photoredox catalysis can provide a general platform from which to address this challenge. This cross-coupling system uses naturally abundant alkyl carboxylic acids and commercially available nitrogen nucleophiles as coupling partners. It is applicable to a wide variety of primary, secondary and tertiary alkyl carboxylic acids (through iodonium activatio

SUBMITTER: Liang Y 

PROVIDER: S-EPMC6106865 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature