Cross-genetic determination of maternal and neonatal immune mediators during pregnancy.

ABSTRACT:

Background

The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators have been associated with pregnancy complications as well as susceptibility to autoimmune and neurodevelopmental conditions in later life. Evidence suggests that the immune system in adults not only responds to environmental stimulation but is also under strong genetic control.

Methods

This is the first genetic study of > 700 mother-infant pairs to analyse the circulating levels of 22 maternal mid-gestational serum-derived and 42 neonatal bloodspot-derived immune mediators (cytokines/chemokines) in the context of maternal and fetal genotype. We first estimated the maternal and fetal genome-wide SNP-based herit

SUBMITTER: Traglia M 

PROVIDER: S-EPMC6106874 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature