Increased BDNF methylation in saliva, but not blood, of patients with borderline personality disorder.

ABSTRACT: BACKGROUND:The importance of epigenetic alterations in psychiatric disorders is increasingly acknowledged and the use of DNA methylation patterns as markers of disease is a topic of ongoing investigation. Recent studies suggest that patients suffering from Borderline Personality Disorder (BPD) display differential DNA methylation of various genes relevant for neuropsychiatric conditions. For example, several studies report differential methylation in the promoter region of the brain-derived neurotrophic factor gene (BDNF) in blood. However, little is known about BDNF methylation in other tissues. RESULTS:In the present study, we analyzed DNA methylation of the BDNF IV promoter in saliva and blood of 41 BPD patients and 41 matched healthy controls and found significant hypermethylation in t

SUBMITTER: Thomas M 

PROVIDER: S-EPMC6106893 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature