Biocatalytic synthesis of acylated derivatives of troxerutin: their bioavailability and antioxidant properties in vitro.

ABSTRACT:

Background

Flavonoid glycosides have many beneficial effects on health, but these bioactivities tend to decrease after oral administration owing to their poor lipophilicity. In this study, a facile whole-cell-based method was developed for selective preparation of monoester or diester of troxerutin, a flavonoid derivative. In addition, the bioavailabilities and antioxidant properties of troxerutin and its acylated derivatives were also investigated in cells.

Results

Pseudomonas aeruginosa and Pseudomonas stutzeri cells showed high catalytic efficiency (substrate conversion > 90%) and different preferences for troxerutin, resulting in the production of its monoester (TME) and diester (TDE), respectively. The logP values of troxerutin, TME, and TDE were - 2.04 ± 0.10, - 0.75 ±

SUBMITTER: Xin X 

PROVIDER: S-EPMC6106897 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature