Quantifying where human acquisition of antibiotic resistance occurs: a mathematical modelling study.

ABSTRACT:

Background

Antibiotic-resistant bacteria (ARB) are selected by the use of antibiotics. The rational design of interventions to reduce levels of antibiotic resistance requires a greater understanding of how and where ARB are acquired. Our aim was to determine whether acquisition of ARB occurs more often in the community or hospital setting.

Methods

We used a mathematical model of the natural history of ARB to estimate how many ARB were acquired in each of these two environments, as well as to determine key parameters for further investigation. To do this, we explored a range of realistic parameter combinations and considered a case study of parameters for an important subset of resistant strains in England.

Results

If we consider all people with ARB in the total popula

SUBMITTER: Knight GM 

PROVIDER: S-EPMC6106940 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature