Accurate Detection of Convergent Amino-Acid Evolution with PCOC.

ABSTRACT: In the history of life, some phenotypes have been acquired several times independently, through convergent evolution. Recently, lots of genome-scale studies have been devoted to identify nucleotides or amino acids that changed in a convergent manner when the convergent phenotypes evolved. These efforts have had mixed results, probably because of differences in the detection methods, and because of conceptual differences about the definition of a convergent substitution. Some methods contend that substitutions are convergent only if they occur on all branches where the phenotype changed toward the exact same state at a given nucleotide or amino acid position. Others are much looser in their requirements and define a convergent substitution as one that leads the site at which they occur to p

SUBMITTER: Rey C 

PROVIDER: S-EPMC6106957 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature