The Subcellular Distribution of Ryanodine Receptors and L-Type Ca²⁺ Channels Modulates Ca²⁺-Transient Properties and Spontaneous Ca²⁺-Release Events in Atrial Cardiomyocytes.

ABSTRACT: Spontaneous Ca²⁺-release events (SCaEs) from the sarcoplasmic reticulum play crucial roles in the initiation of cardiac arrhythmias by promoting triggered activity. However, the subcellular determinants of these SCaEs remain incompletely understood. Structural differences between atrial and ventricular cardiomyocytes, e.g., regarding the density of T-tubular membrane invaginations, may influence cardiomyocyte Ca²⁺-handling and the distribution of cardiac ryanodine receptors (RyR2) has recently been shown to undergo remodeling in atrial fibrillation. These data suggest that the subcellular distribution of Ca²⁺-handling proteins influences proarrhythmic Ca²⁺-handling abnormalities. Here, we employ computational modeling to provide an in-depth analy

SUBMITTER: Sutanto H 

PROVIDER: S-EPMC6107030 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature