Stronger prediction of motor recovery and outcome post-stroke by cortico-spinal tract integrity than functional connectivity.

ABSTRACT: OBJECTIVES:To examine longitudinal changes in structural and functional connectivity post-stroke in patients with motor impairment, and define their importance for recovery and outcome at 12 months. METHODS:First-time stroke patients (N = 31) were studied at 1-2 weeks, 3 months, and 12 months post-injury with a validated motor battery and resting-state fMRI to measure inter-hemispheric functional connectivity (FC). Fractional anisotropy (FA) of the cortico-spinal tract (CST) was derived from diffusion tensor imaging as a measure of white matter organization. ANOVAs were used to test for changes in FC, FA, and motor performance scores over time, and regression analysis related motor outcome to clinical and neuroimaging variables. RESULTS:FA of the ipsilesional CST improved significantly fro

SUBMITTER: Lin LY 

PROVIDER: S-EPMC6107181 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature