Expression of immunohistochemical markers in non-oropharyngeal head and neck squamous cell carcinoma in Ghana.

ABSTRACT:

Background

Head and neck cancers include carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx. Studies on molecular expression of prognostic tumour markers in Ghana are scarce. The purpose of this study was to determine the expression of p53, p16, EGFR, Cyclin-D1 and HER2 among patients with non-oropharyngeal head and neck squamous cell carcinoma (HNSCC).

Methodology

Tissue microarrays from 154 histologically confirmed non-oropharyngeal HNSCC at the Komfo Anokye Teaching Hospital from 2006-2014 were constructed using duplicate cores of representative and viable areas from tumours. Expression of EGFR, p53, p16, Cyclin-D1 and HER2 was evaluated using immunohistochemistry.

Results

For non-oropharyngeal HNSCC, majority of the cases (66.2%; 102/154) had s

SUBMITTER: Owusu-Afriyie O 

PROVIDER: S-EPMC6107249 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature