Control of human gene expression: High abundance of divergent transcription in genes containing both INR and BRE elements in the core promoter.

ABSTRACT: BACKGROUND:DNA sequence elements in the core promoter can play a central role in regulation of gene expression. Core elements (e.g. INR and TATA box) are located within ~50bp of the transcription start site and both upstream and downstream elements are known. Although all can affect the level of gene expression, their mechanism of action has yet to be fully defined. The studies described here are focused on two core promoter elements, INR and BRE, in the human genome. The locations of the two elements were determined in a large number of human promoters and the results were interpreted in terms of overall promoter function. RESULTS:A total of 13,406 promoters were collected from the reference version of the human genome and found to contain 62,891 INR sequences and 32,290 BRE. An INR seque

SUBMITTER: Brown JC 

PROVIDER: S-EPMC6107252 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature