Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap.

ABSTRACT: Recent studies suggest that some monoclonal antibodies (mAbs) specific for ebolavirus glycoprotein (GP) can protect experimental animals against infections. Most mAbs isolated from ebolavirus survivors appeared to target the glycan cap or the stalk region of the viral GP, which is the envelope protein and the only antigen inducing virus-neutralizing antibody response. Some of the mAbs were demonstrated to be protective in vivo. Here, a panel of mAbs from four individual survivors of ebolavirus infection that target the glycan cap or stem region were selected for investigation of the mechanisms of their antiviral effect. Comparative characterization of the inhibiting effects on multiple steps of viral replication was performed, including attachment, post-attachment, entry, binding at low pH

SUBMITTER: Ilinykh PA 

PROVIDER: S-EPMC6107261 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature