Pulmonary influenza A virus infection leads to suppression of the innate immune response to dermal injury.

ABSTRACT: The innate immune system is responsible for many important functions in the body including responding to infection, clearing cancerous cells, healing wounds, and removing foreign substances. Although many of these functions happen simultaneously in life, most laboratory studies of the innate immune response focus on one activity. How the innate immune system responds to concurrent insults in different parts of the body is not well understood. This study explores the impact of a lung infection on the cutaneous wound healing process. We used two complimentary models of injury: the excisional tail wound and subcutaneous implantation of polyvinyl alcohol (PVA) sponges. These models allow for assessment of the rate of closure and measurement of cellular and cytokine responses during acute wound

SUBMITTER: Crane MJ 

PROVIDER: S-EPMC6107272 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature