Optimization of selective inversion recovery magnetization transfer imaging for macromolecular content mapping in the human brain.

ABSTRACT:

Purpose

To optimize a selective inversion recovery (SIR) sequence for macromolecular content mapping in the human brain at 3.0T.

Theory and methods

SIR is a quantitative method for measuring magnetization transfer (qMT) that uses a low-power, on-resonance inversion pulse. This results in a biexponential recovery of free water signal that can be sampled at various inversion/predelay times (t_I/ t_D ) to estimate a subset of qMT parameters, including the macromolecular-to-free pool-size-ratio (PSR), the R₁ of free water (R_1f ), and the rate of MT exchange (k_mf ). The adoption of SIR has been limited by long acquisition times (≈4 min/slice). Here, we use Cramér-Rao lower bound theory and data reduction strategies to select op

SUBMITTER: Dortch RD 

PROVIDER: S-EPMC6107392 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature