Technique development of 3D dynamic CS-EPSI for hyperpolarized ¹³ C pyruvate MR molecular imaging of human prostate cancer.

ABSTRACT:

Purpose

The purpose of this study was to develop a new 3D dynamic carbon-13 compressed sensing echoplanar spectroscopic imaging (EPSI) MR sequence and test it in phantoms, animal models, and then in prostate cancer patients to image the metabolic conversion of hyperpolarized [1-¹³ C]pyruvate to [1-¹³ C]lactate with whole gland coverage at high spatial and temporal resolution.

Methods

A 3D dynamic compressed sensing (CS)-EPSI sequence with spectral-spatial excitation was designed to meet the required spatial coverage, time and spatial resolution, and RF limitations of the 3T MR scanner for its clinical translation for prostate cancer patient imaging. After phantom testing, animal studies were performed in rats and transgenic mice with prostate cancers. F

SUBMITTER: Chen HY 

PROVIDER: S-EPMC6107425 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature