Human-origin probiotic cocktail increases short-chain fatty acid production via modulation of mice and human gut microbiome.

ABSTRACT: The gut bacteria producing metabolites like short-chain fatty acids (SCFAs; e.g., acetate, propionate and butyrate), are frequently reduced in Patients with diabetes, obesity, autoimmune disorders, and cancers. Hence, microbiome modulators such as probiotics may be helpful in maintaining or even restoring normal gut microbiome composition to benefit host health. Herein, we developed a human-origin probiotic cocktail with the ability to modulate gut microbiota to increase native SCFA production. Following a robust protocol of isolation, characterization and safety validation of infant gut-origin Lactobacillus and Enterococcus strains with probiotic attributes (tolerance to simulated gastric and intestinal conditions, adherence to intestinal epithelial cells, absence of potential virulence g

SUBMITTER: Nagpal R 

PROVIDER: S-EPMC6107516 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature