The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens.

ABSTRACT: A C1858T single nucleotide polymorphism within PTPN22 (which encodes PTPN22^R620W) is associated with an enhanced susceptibility to multiple autoimmune diseases including type 1 diabetes and rheumatoid arthritis. Many of the associated autoimmune diseases have an autoantibody component to their pathology. Fc receptors (FcRs) recognise autoantibodies when they bind to autoantigens and form immune complexes. After immune complex binding and receptor crosslinking, FcRs signal via Src and Syk family kinases, leading to antigen uptake, presentation and cytokine secretion. Ptpn22 encodes a protein tyrosine phosphatase that negatively regulates Src and Syk family kinases proximal to immunoreceptor signalling cascades. We therefore hypothesised that PTPN22 regulates immune complex stimul

SUBMITTER: Clarke F 

PROVIDER: S-EPMC6107551 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature