Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia.

ABSTRACT: Nanomagnetic hyperthermia (NMH) is intensively studied with the prospect of cancer therapy. A major challenge is to determine the dissipated power during in vivo conditions and conventional methods are either invasive or inaccurate. We present a non-calorimetric method which yields the heat absorbed during hyperthermia: it is based on accurately measuring the quality factor change of a resonant radio frequency circuit which is employed for the irradiation. The approach provides the absorbed power in real-time, without the need to monitor the sample temperature as a function of time. As such, it is free from the problems caused by the non-adiabatic heating conditions of the usual calorimetry. We validate the method by comparing the dissipated power with a conventional calorimetric measureme

SUBMITTER: Gresits I 

PROVIDER: S-EPMC6107667 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature