Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality.

ABSTRACT: Magnetic iron oxide nanoparticles (MIONs) have established a niche as a nanomedicine platform for diagnosis and therapy, but they present a challenging surface for ligand functionalization which limits their applications. On the other hand, coating MIONs with another material such as gold to enhance these attachments introduces other complications. Incomplete coating may expose portions of the iron oxide core, or the coating process may alter their magnetic properties. We describe synthesis and characterization of iron oxide/silica/gold core-shell nanoparticles to elucidate the effects of a silica-gold coating process and its impact on the resulting performance. In particular, small angle neutron scattering reveals silica intercalates between iron oxide crystallites that form the dense cor

SUBMITTER: Woodard LE 

PROVIDER: S-EPMC6107675 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature