Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance.

ABSTRACT: Memory is indispensable for normal cognitive functioning, and the ability to store and retrieve information is central to mental health and disease. The molecular mechanisms underlying complex memory functions are largely unknown, but multiple genome-wide association studies suggest that gene regulation may play a role in memory dysfunction. We performed a global gene expression analysis using a large and balanced case-control sample (n = 754) consisting of healthy controls and schizophrenia and bipolar disorder patients. Our aim was to discover genes that are differentially expressed in relation to memory performance. Gene expression in blood was measured using Illumina HumanHT-12 v4 Expression BeadChip and memory performance was assessed with the updated California Verbal Learning Test (

SUBMITTER: Akkouh IA 

PROVIDER: S-EPMC6107676 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature