Adherence and long-term growth outcomes: results from the easypod^™ connect observational study (ECOS) in paediatric patients with growth disorders.

ABSTRACT:

Objective

The easypod connect observational study (ECOS) assessed treatment adherence among paediatric patients receiving growth hormone (GH) via the easypod electronic injection device.

Design

ECOS was an open-label, observational, longitudinal study conducted in 24 countries between 2010 and 2016, enrolling children treated with GH.

Methods

The primary endpoint was the rate of treatment adherence during 5 years of follow-up. Impact of adherence on growth outcomes was assessed using Spearman's product-moment correlations.

Results and conclusions

Overall, 1190 patients had easypod data available for ≥3 months; most patients had GH deficiency (75%); 606 of these patients were GH naïve at baseline. Over the first year of monitoring, the median rate of adherence w

SUBMITTER: Koledova E 

PROVIDER: S-EPMC6107763 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature