Mass cytometry of Hodgkin lymphoma reveals a CD4⁺ regulatory T-cell-rich and exhausted T-effector microenvironment.

ABSTRACT: In classical Hodgkin lymphoma (cHL), the host antitumor immune response is ineffective. Hodgkin Reed-Sternberg (HRS) cells have multifaceted mechanisms to evade the immune system, including 9p24.1/CD274(PD-L1)/PDCD1LG2(PD-L2) genetic alterations, overexpression of PD-1 ligands, and associated T-cell exhaustion and additional structural bases of aberrant antigen presentation. The clinical success of PD-1 blockade in cHL suggests that the tumor microenvironment (TME) contains reversibly exhausted T effector cells (Teffs). However, durable responses are observed in patients with β2-microglobulin/major histocompatibility complex (MHC) class I loss on HRS cells, raising the possibility of non-CD8⁺ T cell-mediated mechanisms of efficacy of PD-1 blockade. These observations high

SUBMITTER: Cader FZ 

PROVIDER: S-EPMC6107878 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature