Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death. While cigarette smoking is the primary cause of this malignancy, risk differs across racial/ethnic groups. For the same number of cigarettes smoked, Native Hawaiians compared to whites are at greater risk and Japanese Americans are at lower risk of developing lung cancer. DNA methylation of specific CpG sites (e.g., in AHRR and F2RL3) is the most common blood epigenetic modification associated with smoking status. However, the influence of internal smoking dose, measured by urinary nicotine equivalents (NE), on DNA methylation in current smokers has not been investigated, nor has a study evaluated whether for the same smoking dose, circulating leukocyte DNA methylation patterns differ by race.

Methods

We co

SUBMITTER: Park SL 

PROVIDER: S-EPMC6108111 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature